During the 2016 season, three weekly NRL matches will be aired on NBC as well as Digicel Play. The partnership will also see the ANZAC Test and the very popular State of Origin series aired on both networks.All remaining matches, including the PNG Hunters games and Digicel Cup, will be aired on Digicel Play.Digicel CEO, Mr Maurice McCarthy, said Digicel recognises that Rugby League and the NRL has a passionate following in PNG.”We want to work closely with PNG’s state broadcaster to allow both our viewers and NBC viewers the chance to see the action at home,” he said.”As the true home of Rugby League in PNG, Digicel Play offers an unbeatable service for our viewers. With Digicel Play and NBC we are reaching the whole of PNG.””PNG is going to experience NRL like they have never experienced it before and our partnership with NBC means key games will be free-to-air on NBC, as well as broadcast in high definition on Digicel Play,” Mr McCarthy said.Acting Managing Director of NBC, Kora Nou, said the availability of the NRL in every home in PNG with a TV set, and meant that the partnership was a win-win arrangement for both the NBC and Digicel Play.”We recognize that Rugby League is the national sport of PNG, and the NRL is the best club competition in the world. Through this partnership, there will be 100 percent NRL coverage across the country. Working together with Digicel means that the people of PNG can enjoy the NRL on whichever platform they choose.”As the State Broadcaster, one of our core functions is to provide real entertainment; when it comes to Rugby League, the NRL is as compelling as it gets,” he said.
Jul 31 2018A gene that’s associated with an autoimmune form of hair loss could be exploited to improve cancer immunotherapy, suggests a new mouse study by Columbia University Irving Medical Center (CUIMC) researchers.The paper was published on line last month in the journal Cell Systems.”While immunotherapies have shown great promise in cancer, most patients do not benefit from these treatments because their tumors are able to evade the immune system,” said study leader Angela M. Christiano, PhD, the Richard and Mildred Rhodebeck Professor of Dermatology and Genetics and Development at Columbia University Vagelos College of Physicians and Surgeons. “But one way around this obstacle is to harness genes that cause the recruitment of T cells in autoimmune disease, and use them to attract T cells to kill tumors. In this study, we showed that a gene that recruits T cells in alopecia areata–a condition in which immune cells attack and destroy hair cells–is turned off in various types of cancer, protecting them from the immune system. But if we turn that gene back on, we can make those cancers vulnerable to the immune response.”The study began with the recognition that autoimmune diseases and cancer represent opposite ends of the immune signaling spectrum. When the immune system is overactive, a patient may be at risk for autoimmune disease; when it’s underactive, cancer can evade the immune system and progress.”We should be able to identify genetic signals that are hyperactive in autoimmune disease, and then harness those signals in tumors that have developed a way to avoid the immune response,” said lead author James Chen, PhD, a precision medicine fellow at CUIMC.In a previous study, the research team identified such a genetic signal–a gene called named IKZF1–in alopecia areata. In this condition, an overactive IKZF1 gene leads to overproduction of immune cells, killing the hair follicles.”The key immune cells in alopecia areata are the same cells that many cancers can evade. These so-called killer T cells are crucial for the success of cancer immunotherapies,” said Christiano.In this study, the researchers investigated whether they could activate IKZF1 in tumor cells in order to attract T cells to tumors, mobilizing them to attack the cancer.Using an algorithm designed by Chen, the researchers screened genomic and bioinformatic data on thousands of cancer patients in the Cancer Genome Atlas, searching for tumor types that had IKZF1 in their regulatory networks. The algorithm predicted several types of cancer, including melanoma, that would be amenable to targeted immunotherapy, and two types that would not.Related StoriesUsing machine learning algorithm to accurately diagnose breast cancerBacteria in the birth canal linked to lower risk of ovarian cancerLiving with advanced breast cancerThe predictions were first tested in a mouse model of melanoma in which the tumors were genetically modified to express IKZF1. The mice were found to have increased levels of infiltrating immune cells in their tumors, compared to control mice with conventional melanoma, a sign that the tumors had lost as least some ability to evade the immune response.”We were particularly struck that IKZF1-expressing tumors responded significantly better to anti-PD-1 and anti-CTLA-4 treatment. Tumor growth was almost completely suppressed,” said study co-author Charles G. Drake, MD, PhD, professor of medicine and director of genitourinary oncology at Columbia University Vagelos College of Physicians and Surgeons, co-director of the immunotherapy program, and associate director for clinical research of the Herbert Irving Comprehensive Cancer Center at CUIMC.The team then analyzed data from a previous study of melanoma patients with disabled IKZF1. Patients with disabled IKZF1 had higher recurrence rates and worse survival compared to other melanoma patients.The team is currently searching for additional candidate genes that can similarly be used to enhance the response to immunotherapy in melanoma.The algorithm also predicted that prostate cancer could be made more responsive to immunotherapy. In lab experiments, the team found that restoring IKZF1 activity in prostate tumor cells made them susceptible to immunotherapies. “Clinically, this is an especially exciting finding, since prostate cancer is generally very poorly infiltrated by immune cells. Turning these ‘cold’ tumors ‘hot’ could be a key to therapeutic success,” said Drake.In addition, the algorithm correctly predicted that colorectal and kidney tumors would not respond to immunotherapy if IKZF1 expression was increased, since the gene was found to be inactive in these tumors.Therapies based on these findings would be years away, in large part because different approaches would be needed to activate IKZF1 in humans. However, the approach could be used soon to predict whether patients are likely to respond to immunotherapy and to assess their prognosis. Source:http://newsroom.cumc.columbia.edu/blog/2018/07/30/harnessing-hair-loss-gene-could-improve-cancer-immunotherapy/